Effects of Cholestasis on Whole Blood Concentration of Tacrolimus, an Immunosuppressant, in Living-R

• 作 者: Shinji Kobuchi Keizo Fukushima
• 机 构: 4DepartmentofTransplantationandRegenerativeSurgery,DepartmentofClinicalPharmacokinetics,Departmentof
• 出 处: 临床医学国际期刊(英文)
• 发表日期: 2013年10期
• 关键词: Pharmacokinetics Bile Duct STRICTURE TACROLIMUS DRUG Metabolism Total BILIRUBIN

Background: To explore the effects of cholestasis on whole blood concentration of tacrolimus (TAC), an immunosup-pressant, we investigated the relationship among blood TAC concentration, bile flow, and TAC metabolites in bile, as well as the relationship