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【目的】研究中国人TGFβ1-509C/T基因多态性与不同病理类型及中医证型胃癌遗传易感性的关系及其对胃癌患者预后的影响。【方法】采用限制性长度片段多态性(RFLP)对648例胃癌及781例正常对照进行TGFβ1-509位点基因分型,分析不同证型及病理学特点的胃癌发病风险。【结果】携带TGFβ1-509 C等位基因(CT/CC)发生胃癌的风险较TT基因型显著降低(OR=0.66,P<0.001),且与肠型胃癌(OR=0.65,P<0.001)及实证型胃癌(OR=0.57,P<0.001)显著相关。【结论】TGFβ1-509C/T基因多态性降低胃癌的发病风险,且与病理类型及中医证型等临床病理学特征有关。
【Objective】 To investigate the relationship between genetic polymorphisms of TGFβ1-509C / T and the genetic susceptibility of gastric cancer with different pathological types and TCM syndromes and its effect on the prognosis of patients with gastric cancer. 【Methods】 The TGFβ1-509 loci were genotyped by restriction fragment length polymorphism (RFLP) in 648 gastric cancer patients and 781 healthy controls. The risk of gastric cancer with different syndrome types and pathological features was analyzed. 【Results】 The risk of gastric cancer with TGFβ1-509 C allele (CT / CC) was significantly lower than that of TT genotype (OR = 0.66, P <0.001) And positive gastric cancer (OR = 0.57, P <0.001). 【Conclusion】 TGFβ1-509C / T gene polymorphism reduces the risk of gastric cancer, and is related to the pathological type and the clinicopathological features of TCM syndrome.