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为探讨急性胰腺炎患者血液中细胞因子变化与病情严重度及多器官功能障碍（ＭＯＤ）之间的关系，对１９９４年至１９９６年入院的３６例急性胰腺炎患者依据ＲＡＮＳＯＮ评分和ＣＴ评分将其分为轻型组（１２例）和重型胰腺炎组（２４例），又将重型胰腺炎组中发生ＭＯＤＳ的９例定名为障碍组。在入院第０、４、８天测定血清ＴＮＦ、ＩＬ６、ＣＲＰ值。结果显示胰腺炎早期患者血液中细胞因子在轻型组、重型组和障碍组之间依次升高，并有显著性差异（Ｐ＜０．０５）。由此表明急性胰腺炎细胞因子升高与疾病严重度和并发症发生有关，极度升高者可能发生多器官衰竭，动态检测上述细胞因子有助于判断患者的预后
To investigate the relationship between the changes of cytokines in blood and the severity of multiple organ dysfunction (MOD) in patients with acute pancreatitis, 36 patients with acute pancreatitis admitted from 1994 to 1996 were selected according to RANSON score and CT score Divided into light group (12 cases) and severe pancreatitis group (24 cases), again in severe pancreatitis group occurred in 9 cases of MODS as the obstacle group. In admission 0,4,8 days determination of serum TNF, IL 6, CRP value. The results showed that in the early stage of pancreatitis, the levels of cytokines in the blood increased in turn between the light group, the heavy group and the obstacle group, and there was a significant difference (P <0.05). This shows that elevated acute pancreatitis cytokines and the severity of the disease and complications related to extreme increase may occur multiple organ failure, dynamic detection of these cytokines help determine the prognosis of patients