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目的通过比较腹腔内大小剂量化疗的疗效,同时观察肿瘤局部及外周血中化疗药的药代变化,比较两种疗法的疗效优劣。方法建立黑色素瘤移植鼠模型;分别观察比较大(12mg/kg)小(4mg/kg)剂量顺铂行腹腔内注射后荷瘤鼠的腹膜瘤结节减少情况,并取鼠大网膜及外周血测定含铂量。结果在动物实验中,与空白对照相比,大小剂量顺铂组瘤结节数量均明显减少;用药后第3、6天时,大剂量顺铂组瘤结节为(126.00±13.68)、(168.17±15.14),而小剂量顺铂组瘤结节分别为(91.17±13.83)、(92.00±11.33),后者明显少于前者,且(P<0.01);用药后第6天时小剂量顺铂组大网膜内含铂量为(997.79±280.08)ng/g,明显高于大剂量顺铂组的(471.29±280.08)ng/g,(P<0.05);小剂量顺铂组外周血中含铂量在用药后均明显低于大剂量顺铂组,(P<0.05)。结论腹腔内化疗能明显减少小鼠腹腔内瘤结节的形成;与一次大剂量化疗相比,小剂量连续化疗疗效更好。
Objective By comparing the efficacy of intra-abdominal size and dose chemotherapy, while observing the drug changes in local and peripheral blood chemotherapeutic drugs, compared the two curative effect. Methods The murine model of melanoma was established. The reduction of peritoneal nodules of the tumor-bearing mice after the intraperitoneal injection of cisplatin (12mg / kg) and small dose (4mg / kg) Blood determination of platinum content. Results In animal experiments, the number of tumor nodules in both large and small doses of cisplatin was significantly reduced compared with the blank control group. On the 3rd and 6th day after treatment, the tumor nodules were (126.00 ± 13.68) and (168.17 ± 15.14), while the low-dose cisplatin group had (91.17 ± 13.83) and (92.00 ± 11.33) tumor nodules, which were significantly less than the former (P <0.01) The content of platinum in the omentum was (997.79 ± 280.08) ng / g, which was significantly higher than that in the high-dose cisplatin group (471.29 ± 280.08 ng / g, P <0.05) The content of platinum was significantly lower than that of high-dose cisplatin group after treatment (P <0.05). Conclusion Intraperitoneal chemotherapy can significantly reduce the formation of intra-abdominal tumor nodules in mice; compared with a large dose of chemotherapy, small doses of continuous chemotherapy is better.