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目的 研究微血管密度 (MVD)与原发性十二指肠癌的病理生物学行为的关系。方法 35例手术后病理证实的原发性十二指肠癌 ,应用免疫组化S P法研究所选标本的MVD值。结果 MVD与十二指肠癌组织分化有关 ,高分化癌肿MVD值低于中低分化癌肿的MVD值 ,二者有显著性差异 ;MVD与十二指肠癌的淋巴和血行转移有关 ,低MVD组的肿瘤转移率低于高MVD组 ;而低MVD组的手术切除率高于高MVD组 ,统计学处理有显著性差异。结论 ①MVD与十二指肠癌的某些病理生物学行为相关。②MVD值对判断十二指肠癌的转移及预后有重要参考价值
Objective To study the relationship between microvessel density (MVD) and the pathological biological behavior of primary duodenal cancer. Methods Thirty-five patients with pathologically confirmed primary duodenal cancer were studied for MVD by immunohistochemical SP method. Results MVD was related to the differentiation of duodenal cancer tissue. The MVD value of well-differentiated cancer was lower than that of moderately-differentiated cancer, and there was a significant difference between them. MVD was related to the lymphatic and hematogenous metastasis of duodenal cancer. The tumor metastasis rate in the low MVD group was lower than that in the high MVD group, while the surgical resection rate in the low MVD group was higher than that in the high MVD group. Statistically significant differences were noted. Conclusion 1MVD is related to some pathological biological behaviors of duodenal cancer. 2MVD value has important reference value for judging the metastasis and prognosis of duodenal cancer