【摘 要】
：
AIM: To characterize the gene expression profiles in differentstages of carcinogenesis of esophageal epithelium.METHODS: A microarray containing 588 cancer rela
【机 构】
：
National Laboratory of Molecular Oncology, Cancer Institute, Peking Union Medical College and Chines
论文部分内容阅读
AIM: To characterize the gene expression profiles in differentstages of carcinogenesis of esophageal epithelium.METHODS: A microarray containing 588 cancer relatedgenes was employed to study the gene expression profileat different stages of esophageal squamous cell carcinomaincluding basal cell hyperplasia, high-grade dysplasia,carcinoma in situ, early and late cancer. Principle componentanalysis was performed to search the genes which wereimportant in carcinogenesis.RESULTS: More than 100 genes were up or down regulatedin esophageal epithelial cells during the stages of basal cellhyperplasia, high-grade dysplasia, carcinoma in situ, earlyand late cancer. Principle component analysis identified aset of genes which may play important roles in the tumordevelopment. Comparison of expression profiles betweenthese stages showed that some genes, such as P160ROCK,JNK2, were activated and may play an important role inearly stages of carcinogenesis. CONCLUSION: These findings provided an esophagealcancer-specific and stage-specific expression profiles,showing that complex alterations of gene expression underliethe development of malignant phenotype of esophagealcancer cells.
其他文献
在糖尿病治疗实践中,经常会遇到患者血糖控制得一直很好,但还是出现视物模糊、手脚发凉、乏力、瘙痒、麻木、疼痛、跛行,甚至缺血性溃疡或坏疽等慢性并发症的表现,即便反复调
目的探讨Neuroform颅内支架结合弹簧圈治疗颅内宽颈和梭形动脉瘤的应用价值.方法本组宽颈和梭形动脉瘤45例,采用微导管技术将支架两端跨越动脉瘤颈后释放.18例通过支架的网眼
In the past few years, a variety of extradigestive disorders,including cardiovascular, skin, rheumatic and liver diseases,have been associated with Helicobacter
目的:探讨综合护理干预对乳腺癌术后化疗行PICC置管患者自护能力的影响.方法选取2016年12月至2018年6月在我院行化疗的乳腺癌术后患者38例,随机分为综合组与常规组,每组19例.
目的探索经会阴认知融合MRI前列腺靶向穿刺活检与系统前列腺穿刺活检对前列腺癌诊断率的差异性。方法选择怀疑前列腺癌未曾行前列腺穿刺、前列腺特异性抗原(PSA)≤50.Ong/ml
目的:探讨针对下肢骨折病人的手术护理方法.方法:纳入96例下肢骨折患者于2017.11～2018.12在我院手术室开展研究.依据楼层单双号随机选出48例进行常规手术护理(护理1组),另外48
目的 探讨中老年原发性高血压的危险因素.方法 综合分析610例中老年原发性高血压患者的临床资料.结果 610例患者中偏瘦+体重正常的比率为41.8%(255/610),超重+轻度肥胖+重度肥胖的比率为58.2%(355/610),两者比较差异无统计学意义(P＞0.05).单因素分析表明,中老年原发性高血压患者心血管疾病的危险因素主要有年龄≥60岁、经常吸烟、经常食用高盐食物、不运动.结论 中老年原
一项新的研究发现,如果糖尿病患者出现糖尿病足并发症,出现认知功能缺损的风险就会明显增加.rn负责这项研究的研究者指出:糖尿病与认知功能衰退具有明显的关联.糖尿病是一种
目的进行重组人胰岛素40/60混合注射液的药代、药效动力学研究，并与重组人胰岛素30/70混合制剂、常规型胰岛素、中性鱼精蛋白胰岛素进行比较。方法本研究为阳性对照、单次剂量、开放标签、拉丁方交叉研究。2006年5月至2007年3月招募男性健康受试者20名分为4组，分别在4个试验日进行重组人胰岛素40/60混合、重组人胰岛素30/70混合、常规型胰岛素、中性鱼精蛋白胰岛素注射液4种制剂研究，每次试验