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目的:观察卡托普利能否抑制肾上腺糖皮质激素(激素)治疗肾病综合征(NS)过程中增加尿蛋白排泄量(UPro)和肾小球滤过膜通透性的作用,了解激素上述作用与肾素-血管紧张素-醛固酮系统的关系。方法:原发性及继发性NS患者分成两组,A组15例观察使用强的松1 mg/kg前后UPro及大、中、小分子蛋白的构成比的变化;B组14例NS,观察使用强的松1 mg/kg及卡托普利50mg前后上述指标的变化。结果:A、B两组用药后UPro及大、中分子蛋白构成比都显著增高,小分子蛋白构成比则显著下降。结论:卡托普利不能阻抑,或不能完全阻抑激素对NS患者UPro及肾小球滤过膜通透性增加的作用;激素上述作用与肾素-血管紧张素-醛固酮系统无关或相关不密切。
OBJECTIVE: To observe whether captopril can inhibit the increase of urinary protein excretion (UPro) and glomerular filtration membrane permeability in the process of adrenal glucocorticoid (hormone) treatment of nephrotic syndrome (NS) Relationship with renin - angiotensin - aldosterone system. Methods: The patients with primary and secondary NS were divided into two groups. Group A (15 cases) was used to observe the changes of constituent ratio of UPro and large, medium and small proteins before and after prednisone 1 mg / kg. In group B, 14 cases of NS, To observe the use of prednisone 1 mg / kg and captopril 50mg before and after the above changes. Results: After administration of A and B, UPro, large and medium molecular protein composition ratio were significantly increased, while the small molecule protein composition ratio decreased significantly. CONCLUSION: Captopril does not inhibit, or does not completely inhibit, the effects of hormones on UPro and glomerular filtration membrane permeability in NS patients. The above effects of hormones have nothing to do with the renin-angiotensin-aldosterone system Not close.