The anti-inflammatory activity of garden egg(Solanuni aethiopicum) on egg albumin-induced oedema and

• 作 者: Anosike Chiuma Assumpta Onyechi Obidoa Lawrence U S Ezeanyika
• 机 构: Department of Biochemistry,University of Nigeria,Nsukka,Enugu State,Nigeria,Department of Biochemist
• 出 处: Asian Pacific Journal of Tropical Medicine
• 发表日期: 2012年01期
• 关键词: granuloma garden albumin flank killed cotton doses implantation fruits fresh

Objective:To evaluate the possible anti-inflammatory effect of garden egg[Solatium aethiopieum (S.aethiopieum)]using experimentally induced inflammatory models in rals.Methods:Oedema was induced on the rat hind paw In the injection of 0.1 mL undiluted fresh egg albumin(pbilogistic agent) into the subplantar surface of the rat paw.Tissue granuloma was induced in the rats by the implantation of two autoelaved cotton pellets(30 mg) under the flank o(previously shaved back of anaesthetised rats.Garden egg extract doses were administered to the rats for seven consecutive davs.On dav 8.the animals were killed and the pellets surrounded by granuloma tissue were disseeled out and dried.Results:Extracts of garden egg significanlly(P<0.05) reduced the fresh egg albumin-induced ral paw oedema and also significantly(P<0.05) reduced the granuloma tissue formation in the treated groups when compared to the control.Conclusions:This stud) shows that the fruits of garden egg(S.aethiopieum) have anti-inflammatory activity in the models studied.

Objective: To evaluate the possible anti-inflammatory effect of garden egg [Solatium aethiopieum (S. aethiopieum)] using experimentally induced inflammatory models in rals.Methods: Oedema was induced on the rat hind paw In the injection of 0.1 mL undiluted fresh egg albumin (pbilogistic agent) into the subplantar surface of the rat paw.Tissue granuloma was induced in the rats by the implantation of two autoelaved cotton pellets (30 mg) under the flank o (previously shaved back of anaesthetized rats. Garden egg extract doses were administered to the rats for seven consecutive davs.On dav 8. the animals were killed and the pellets surrounded by granuloma tissue were dissected out and dried. Results: Extracts of garden egg significanly (P <0.05) reduced the fresh egg albumin-induced ral paw oedema and also significantly (P <0.05) reduced the granuloma tissue formation in the treated groups when compared to the control. Conclusions: This stud shows that the fruits of garden egg (S. aethiopieum) have anti-in flammatory activity in the models studied.