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为了研究温热重蒸馏水合并顺铂腹腔内灌注对晚期胃癌患者术后的抗癌作用,作者对42例晚期胃癌患者,在施行姑息性胃大部或全胃切除术后,随机分为治疗组22例,对照组20例,并分别给予温热(43℃)重蒸馏水合并顺铂及常温生理盐水腹腔内灌注处理。结果显示:温热重蒸馏水合并顺铂腹腔内灌注可杀灭腹膜腔内游离癌细胞,阻止或明显推迟腹水及腹膜癌结节的生长,延长生存期,其1年生存率和1.5年生存率,治疗组(81.8%、72.7%)与对照组(45.0%、40.0%)相比,有非常显著性差异(P<0.01),治疗组2年生存率(54.5%)亦高于对照组(34.0%),P>0.05。因此作者认为,温热重蒸馏水合并顺铂腹腔内灌注是晚期胃癌患者术后的重要辅助治疗方法之一,有待作更远期的疗效观察。
To investigate the effect of intraperitoneal instillation of warm redistilled water combined with cisplatin on postoperative anticancer activity in patients with advanced gastric cancer, the authors randomly assigned the treatment group to 42 patients with advanced gastric cancer after palliative gastrectomy or total gastrectomy. Twenty-two patients in the control group and 20 in the control group were given intraperitoneal perfusion with warm distilled water (43°C) and distilled water combined with cisplatin and normal temperature saline. The results showed that warm redistilled water combined with intraperitoneal instillation of cisplatin can kill free cancer cells in the peritoneal cavity, prevent or significantly delay the growth of ascites and peritoneal cancer nodules, prolong survival, and have a one-year survival rate of 1.5 years. The survival rate was significantly higher in the treatment group (81.8%, 72.7%) than in the control group (45.0%, 40.0%) (P<0.01). The treatment group was 2 years old. The survival rate (54.5%) was also higher than the control group (34.0%), P>0.05. Therefore, the author believes that warm redistillation of water combined with cisplatin intraperitoneal perfusion is an important adjuvant treatment for patients with advanced gastric cancer after surgery, pending further efficacy observation.