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目的 :分析丙戊酸钠 (VPA)治疗儿童癫血药浓度与量 效关系。方法 :以荧光偏振免疫法 (FPIA)对 81例癫患儿进行VPA血药浓度监测。结果 :有效控制癫发作的浓度为 (6 0 7± 13 7) μg·mL-1,其中 5 0～ 10 0 μg·mL-1范围的占 73 7%。结论 :血药浓度对VPA治疗癫的个体化用药具有重要的临床意义
Objective: To analyze the relationship between plasma concentration of epirubicin and VPA in children. Methods: The plasma concentrations of VPA in 81 epileptic children were monitored by fluorescence polarization immunoassay (FPIA). Results: The effective control of epileptic seizures was (6 0 7 ± 13 7) μg · mL -1, of which 73 7% was in the range of 50 ~ 100 μg · mL -1. Conclusion: The plasma concentration has an important clinical significance for the individualized use of VPA in the treatment of epilepsy