论文部分内容阅读
目的本研究拟通过鼻内窥镜手术中应用美托洛尔,观察β-肾上腺素受体阻滞剂对ASAⅠ～Ⅱ级患者术后住院时间的影响。方法气管内麻下行Fess手术患者80例。随机分为实验组和对照组(n=40)。临床观察组术前静脉推注美托洛尔15mg。对照组术中静脉泵注硝普钠。两组患者的麻醉用药一致,两组维持收缩压在80～90mmHg,平均动脉压大于50mmHg,比较两组患者术后住院时间、两组患者乳酸、血糖、血流动力学变化。结果1临床观察组术后住院时间为2～4天,平均(3.33±0.65)天,对照著组术后住院时间3～6天,平均(4.55±0.82)天。两组比较有显著性差异(P=0.001)。2两组患者手术开始后乳酸和血糖都逐渐升高,术后回落。两组患者乳酸(P=0.01)和血糖(P=0.00)的变化趋势明显不同。结论围术期应用美托洛尔能够通过抑制应激反应,缩短ASAⅠ～Ⅱ级患者的术后住院。
Objective To study the effect of β-adrenergic blockers on postoperative hospital stay in patients with ASA grade Ⅰ ~ Ⅱ by metoprolol in nasal endoscopic surgery. Methods 80 patients with Fess underwent endotracheal intubation. Randomly divided into experimental group and control group (n = 40). Clinical observation group preoperative intravenous metoprolol 15mg. The control group intraoperative intravenous sodium nitroprusside. Two groups of patients with consistent anesthesia medication, systolic blood pressure in both groups to maintain 80 ~ 90mmHg, mean arterial pressure greater than 50mmHg, compared two groups of patients hospital stay, two groups of patients with lactic acid, blood glucose, hemodynamic changes. Results 1 The clinical observation group had a postoperative length of stay of 2 to 4 days (average, 3.33 ± 0.65) days, and the control group had an average postoperative stay of 3 to 6 days (4.55 ± 0.82) days. There was significant difference between the two groups (P = 0.001). 2 lactic acid and blood glucose gradually increased after the operation of two groups of patients, postoperatively. The changes of lactic acid (P = 0.01) and blood glucose (P = 0.00) in two groups were significantly different. Conclusion Perioperative application of metoprolol can shorten the postoperative hospitalization of ASA Ⅰ ~ Ⅱ patients by inhibiting the stress response.