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虽然许多抗癌药物应用已有多年,但对其中不少药物在体内的吸收、分布、代谢、排泄过程仍不够清楚,而这些知识对于研究给药时间、方式、充分发挥药物的效力和降低毒副作用都非常必要。近年来,随着药物动力学的发展,对生物药物分析也提出了更高的要求。由于药物在体液内含量很低,生物检体对之干扰较大,因此要求分析方法专一性强且灵敏度高;为了满足临床血药浓度跟踪分析的要求,分析方法还必须快速、简便。最初用于药物动力学研究的分析方法有放射性同位素标记示踪法和微生物测定法。这两种分析方法的优点是不必预先除
Although many anti-cancer drugs have been used for many years, the absorption, distribution, metabolism and excretion of many drugs in the body are still not clear enough. This knowledge is of great significance for studying the time and mode of administration, Side effects are very necessary. In recent years, with the development of pharmacokinetics, biological drug analysis also put forward higher requirements. Due to the low content of the drug in the body fluid and the interference of the biological sample, the analytical method needs strong specificity and high sensitivity. In order to meet the requirements of the clinical plasma concentration tracking analysis, the analysis method must be fast and simple. Analytical methods originally used for pharmacokinetic studies include radioisotope labeling and microbiological assays. The advantage of these two methods of analysis is that they do not have to be removed in advance