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目的探讨包涵体肌炎的临床和病理特点。方法分析20例包涵体肌炎患者的临床、骨骼肌活检组织化学染色及电镜病理特点。结果骨骼肌活检组织化学染色病理特点:肌周膜、肌内膜、血管周围炎性细胞浸润,肌纤维大小不等,散在变性、坏死和再生肌纤维,结缔组织增生,肌纤维内可见边缘空泡,空泡周边淀粉样物质沉积,可伴破碎红纤维、肌纤维类型或分布异常。电镜:肌原纤维结构紊乱,Z 线排列不整或消失,肌浆包涵体内可见大量髓磷脂小体和吞噬空泡聚集,周边可见脂滴、糖原颗粒。结论包涵体肌炎临床诊断、鉴别诊断困难,骨骼肌活检病理分析是确诊本病的可靠标准。
Objective To investigate the clinical and pathological features of inclusion body myositis. Methods Clinical and skeletal muscle biopsies of 20 patients with inclusion body myositis were analyzed by histochemical staining and electron microscopy. Results Skeletal muscle biopsy histopathological features: peri-perimembranous membrane, endomyocardial, perivascular inflammatory cell infiltration, muscle fiber size range, scattered degeneration, necrosis and regeneration of muscle fibers, connective tissue hyperplasia, marginal vacuoles visible in muscle fibers, empty Foam around the deposition of amyloid may be broken with red fibers, muscle fiber types or distribution abnormalities. Electron microscopy: Myofibrillar structure disorders, Z line arranged in an irregular or disappear, sarcolemma in vivo can be seen in a large number of myelin body and phagocytic accumulation, peripheral lipid droplets, glycogen particles. Conclusion Inclusion body myositis clinical diagnosis, differential diagnosis difficult, skeletal muscle biopsy pathological diagnosis is the reliable standard for the diagnosis of the disease.