论文部分内容阅读
目的:探讨中老年人药物不良反应(ADR)的发生特点及规律,为临床安全合理用药提供依据。方法:对2014年8月~2016年8月期间发生药物不良反应的75例患者,从性别、年龄、ADR发生时间、给药途径、药物种类和临床表现等方面进行统计分析。结果:发生药物不良反应时间为用药后5 min~10 d;静脉给药是引发ADR的主要途径,占88.0%(66/75);引起不良反应发生的药物以抗菌药物居首位,占48.0%(36/75),其次为中药制剂,占18.7%(14/75)。其临床表现为皮肤及其附件损害、消化系统损害为主,分别占52.0%(39/75),22.7%(17/75)。结论:加强中老年人药物不良反应的监测工作,是保障患者合理用药、安全的重要措施。
Objective: To investigate the characteristics and regularity of ADR in middle and old aged people and provide basis for safe and rational drug use. Methods: From August 2014 to August 2016, 75 patients who experienced ADRs were analyzed statistically in terms of sex, age, time of ADR, route of administration, drug type and clinical manifestation. Results: Adverse drug reaction time was 5 to 10 days after drug administration. Intravenous drug delivery was the main way to induce ADR, accounting for 88.0% (66/75). Anti-bacterial drug was the most frequently used drug, accounting for 48.0% % (36/75), followed by traditional Chinese medicine preparations, accounting for 18.7% (14/75). The clinical manifestations of damage to the skin and its annexes, digestive system damage, accounting for 52.0% (39/75), 22.7% (17/75). Conclusion: To strengthen the monitoring of adverse drug reactions in the elderly is an important measure to ensure the rational use and safety of patients.