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目的临床观察以质子泵抑制剂奥美拉唑为基础的三联法与以埃索美拉唑为基础的三联法治疗幽门螺杆菌(Hp)阳性胃溃疡60例患者的疗效与评价。方法将60例Hp阳性胃溃疡患者随机分为两组,治疗组口服奥美拉唑、替硝唑、胶体果胶铋,对照组口服埃索美拉唑与克拉霉素、阿莫西林。结果在改善临床症状和溃疡愈合方面,治疗组与对照组比较差异无统计学意义(P>0.05);在Hp转阴率方面,治疗组效果优于对照组(P<0.05)。结论联合使用奥美拉唑、替硝唑、胶体果胶铋的三联疗法比埃索美拉唑、克拉霉素以及阿莫西林三联疗法更能有效治疗Hp阳性胃溃疡,并显著提高Hp转阴率。
Objective To observe the efficacy and evaluation of triple therapy combined with proton pump inhibitor omeprazole and triple therapy with esomeprazole in the treatment of 60 patients with Helicobacter pylori (Hp) -positive gastric ulcer. Methods Sixty patients with Hp-positive gastric ulcer were randomly divided into two groups. Omeprazole, tinidazole and colloidal pectin were administered orally in the treatment group, and esomeprazole, clarithromycin and amoxicillin in the control group. Results There was no significant difference between the treatment group and the control group in improving the clinical symptoms and ulcer healing (P> 0.05). The Hp conversion rate was better in the treatment group than in the control group (P <0.05). Conclusions Triple therapy with omeprazole, tinidazole and colloidal bismuth pectin is more effective than esomeprazole, clarithromycin and amoxicillin triple therapy in treating Hp positive gastric ulcer and significantly increasing Hp negative rate.