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心肌缺血再灌注损伤是心血管疾病领域研究的热点问题之一,目前临床上尚缺乏有效的防治手段。临床研究发现冠心病的绝经前女性患者要明显低于男性患者,说明雌激素在其发生发展过程中具有一定的作用,使雌激素替代疗法逐渐成为新的防治研究热点。大量植物雌激素应用于心血管疾病的预防治疗研究,以期消除合成类雌激素在治疗中副作用。该文总结了雌激素受体在心肌缺血再灌注损伤中的作用,雌激素替代疗法的应用及局限性,以及植物雌激素在其防治过程中的应用前景,以期为开发安全、有效的新型药物提供思路和参考。
Myocardial ischemia-reperfusion injury is one of the hot issues in the field of cardiovascular diseases. At present, there is still a lack of effective prevention and treatment measures in clinical practice. Clinical study found that coronary heart disease in premenopausal women with patients was significantly lower than the male patients, indicating that estrogen in the course of its occurrence and development have a certain role in the estrogen replacement therapy has gradually become a new focus of prevention and treatment. A large number of phytoestrogens used in the prevention and treatment of cardiovascular disease research, with a view to eliminating the side effects of synthetic estrogen in the treatment. This article summarizes the role of estrogen receptor in myocardial ischemia-reperfusion injury, the application and limitations of estrogen replacement therapy, and the application prospects of phytoestrogens in its prevention and treatment in order to develop a safe and effective new Drugs provide ideas and reference.