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目的:观察心理疏导疗法对脑卒中后抑郁症患者的临床疗效及血浆NE、DA、5-HT的干预效应。方法:采用解释、鼓励、支持安慰等方法来疏导患者的心理,治疗2周和4周后对比临床疗效积分的变化及比较治疗前、治疗2周、4周后静脉血血浆NE、DA、5-HT的含量变化。结果:治疗4周后的临床疗效明显优于治疗2周(P<0.05);血浆NE含量治疗2周后较治疗前明显改善(P<0.05),但和治疗4周后差别无统计学意义;DA、5-HT治疗2周后和治疗前的含量差别无统计学意义,但治疗4周后的含量较2周后明显改善(P<0.05)。结论:心理疏导疗法能改善脑卒中后抑郁症患者的临床疗效和血浆NE、DA、5-HT的变化。
Objective: To observe the clinical effect of psychological counseling therapy on post-stroke depression and the intervention effect of plasma NE, DA and 5-HT. Methods: The patients’ psychology was explained by means of explanation, encouragement and supportive comfort. After 2 and 4 weeks of treatment, the changes of clinical efficacy scores were compared and the levels of plasma NE, DA, 5 -HT content changes. Results: After 4 weeks of treatment, the clinical efficacy was significantly better than that of 2 weeks (P <0.05). Plasma NE level was significantly improved after 2 weeks of treatment (P <0.05), but the difference was not statistically significant after 4 weeks of treatment There was no significant difference between DA and 5-HT after two weeks of treatment and before treatment, but the levels of DA and 5-HT after 4 weeks of treatment were significantly improved (P <0.05). Conclusion: Psychological counseling therapy can improve the clinical efficacy and the changes of NE, DA and 5-HT in patients with post-stroke depression.