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对12只麻醉猫进行冠状动脉左前降支(LAD)阻断,观察阻断前和阻新后90分钟内,心室纤颤阈值(VFT)和左室6个地点有效不应期(ERP)。发现LAD阻断后即刻,VFT较基础值下降81±21％(P<0.01);阻断后5分钟内,有4只猫发生自发性心室纤颤(VF),需电击除颤。阻断后即刻,梗塞区不应期离散(DR)从12±4ms至70±23ms(P<0.01),随时间推移,VFT和DR逐渐接近阻断前水平。持续阻断90分钟,VFT和DR呈负相关(r=-0.78,P<0.01)。认为在急性心肌梗塞时,DR可作为衡量心室易颤性的一项可靠指标。
Left anterior descending coronary artery (LAD) was blocked in 12 anesthetized cats. The ventricular fibrillation threshold (VFT) and the left ventricular effective refractory period (ERP) were observed in 90 minutes before and after blocking. Immediately after LAD blockade, VFT decreased by 81 ± 21% (P <0.01) compared with the baseline value. Four cats developed spontaneous ventricular fibrillation (VF) within 5 minutes after blockade, requiring electric shock to defibrillation. Immediately after the blockade, the refractory period (DR) of the infarct zone ranged from 12 ± 4 ms to 70 ± 23 ms (P <0.01). Over time, the VFT and DR gradually approached the pre-block level. Continuous blocking for 90 minutes showed a negative correlation between VFT and DR (r = -0.78, P <0.01). In acute myocardial infarction, DR can be used as a reliable measure of ventricular fibrillation.