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目的:探讨热毒宁注射液治疗小儿轮状病毒性肠炎的临床疗效及安全性。方法:102例腹泻患儿随机分成对照组50例和观察组52例,两组患儿均给予常规对症治疗,对照组患儿给予利巴韦林10 mg·kg-1,ivd,qd,观察组患儿给予热毒宁注射液0.5 ml·kg-1,ivd,qd,3 d为一个疗程。观察两组患儿临床症状消失时间、住院时间及药品不良反应。结果:观察组临床症状消失时间、住院时间均较对照组明显缩短(P<0.05);对照组总有效率为70.0%,观察组总有效率为92.3%,差异有统计学意义(P<0.05)。观察组未见明显药品不良反应,ADR发生率明显低于对照组(P<0.05)。结论:热毒宁注射液治疗小儿轮状病毒性肠炎疗效显著、安全性好,值得临床推广应用。
Objective: To investigate the clinical efficacy and safety of Rendunning injection in treating children with rotavirus enteritis. Methods: A total of 102 children with diarrhea were randomly divided into control group (n = 50) and observation group (n = 52). Both groups were given conventional symptomatic treatment. The control group received ribavirin 10 mg · kg-1, ivd, qd Group given heat poisoning injection 0.5 ml · kg-1, ivd, qd, 3 d for a course of treatment. Two groups of children were observed disappearance of clinical symptoms, hospital stay and adverse drug reactions. Results: The disappearance time and length of hospital stay of the observation group were significantly shorter than those of the control group (P <0.05). The total effective rate was 70.0% in the control group and 92.3% in the observation group, with significant difference (P <0.05 ). There were no obvious adverse drug reactions in the observation group, and the incidence of ADR was significantly lower than that in the control group (P <0.05). Conclusion: Rendunning injection for the treatment of pediatric rotavirus enteritis has obvious curative effect and good safety, which is worthy of clinical application.