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目的:研究中性粒细胞-淋巴细胞比率(NLR)与老年非小细胞肺癌(NSCLC)患者临床病理及预后的相关性分析。方法:回顾性分析我院收治的68例老年NSCLC患者的临床病理资料。根据化疗前NLR分为低NLR组(<2.95)、高NLR组(≥2.95)。比较两组患者临床病理特点及无病生存期(DFS),并分析预后的影响因素。结果:与低NLR组比较,高NLR组临床分期Ⅳ期、吸烟及淋巴转移的比例更大(P<0.05),而两组间年龄、性别、病理类型及合并症比较差异均无统计学意义(P>0.05)。低NLR组中位DFS为7.2个月(95%CI:5.9~8.4),显著高于高NLR组中位DFS 6.7个月(95%CI:5.4~7.9)(P<0.05)。淋巴转移、NLR是老年NSCLC患者DFS的独立危险因素,而年龄、化疗次数则是独立保护因素(P<0.05)。结论:NLR与老年NSCLC患者的临床分期和淋巴结转移有明显相关性,并可作为预后评估参考指标之一。
Objective: To study the correlation between neutrophil-lymphocyte ratio (NLR) and clinicopathologic features and prognosis in elderly patients with non-small cell lung cancer (NSCLC). Methods: The clinical and pathological data of 68 elderly NSCLC patients admitted to our hospital were retrospectively analyzed. According to NLR before chemotherapy, they were divided into low NLR group (<2.95) and high NLR group (≥2.95). The clinicopathological features and disease-free survival (DFS) were compared between the two groups, and the influencing factors of prognosis were analyzed. Results: Compared with the low NLR group, the proportion of stage Ⅳ, smoking and lymph node metastasis in the high NLR group was greater (P <0.05), while there was no significant difference in the age, sex, pathological type and comorbidity between the two groups (P> 0.05). Median DFS in the low NLR group was 7.2 months (95% CI: 5.9 to 8.4), significantly higher than the median DFS 6.7 months (95% CI: 5.4 to 7.9) in the high NLR group (P <0.05). Lymphatic metastasis, NLR is an independent risk factor for DFS in elderly patients with NSCLC, while age and chemotherapy times are independent protective factors (P <0.05). Conclusion: There is a significant correlation between NLR and clinical stage and lymph node metastasis in elderly patients with NSCLC, and may be used as one of the reference indexes for prognosis evaluation.