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本研究结果表明,大鼠妊娠第7～14天每天吸入染毒150mg/m~3、50mg/m~2CS_2,对胎鼠具有明显的致畸作用,主要引起骨骼系统畸形(胸骨缺失、囟门增大)和中枢神经系统畸形(脑室增大)。CS_2还可使孕鼠血清铜、锌含量明显降低,外周血淋巴细胞ANAE阳性率降低。本文还讨论了有关CS_2致畸作用机理的某些问题,认为母体血清铜、锌含量降低可能是CS_2致畸作用机理之一,对母体细胞免疫功能的影响也可能与CS_2的致畸作用机理有关。
The results of this study showed that rats exposed to daily doses of 150 mg / m ~ 3 and 50 mg / m ~ 2 cs 2 on day 7 to 14 of pregnancy had significant teratogenic effects on fetal rats, which mainly caused skeletal system deformities (sternum loss, Large) and central nervous system abnormalities (ventricular enlargement). CS_2 can also make pregnant rats serum copper, zinc content was significantly reduced, peripheral blood lymphocytes ANAE positive rate decreased. The paper also discussed some problems about teratogenic mechanism of CS_2. It is suggested that the decrease of serum copper and zinc may be one of the mechanisms of CS2 teratogenicity, and the effect on the cellular immune function may also be related to the teratogenic mechanism of CS_2. .