论文部分内容阅读
目的:探讨卵巢癌患者中人乳头瘤病毒16/18(HPV_(16/18))感染与免疫球蛋白样转路子-4(ILT-4)表达的相关性。方法:选取2014年1月—2016年12月间收治的获得明确诊断的卵巢上皮良性肿瘤(卵巢上皮良性肿瘤组)、交界性肿瘤(交界性肿瘤组)和卵巢癌(卵巢癌组)患者各45例作为研究对象,另取同期正常卵巢组织者45例作为对照组,采用原位杂交方式检测HPV_(16/18)病毒与ILT-4表达水平,并分析和探讨HPV_(16/18)感染与ILT-4表达的相关性。结果:在卵巢癌患者中,HPV_(16/18)感染度高于对照组、卵巢上皮良性肿瘤组(P<0.05);与交界性肿瘤组比较其差异无统计学意义(P>0.05);卵巢癌患者ILT-4表达水平高于正常对照组、卵巢上皮良性肿瘤组以及交界性肿瘤组(P<0.05)。结论:在卵巢癌中,HPV_(16/18)感染与ILT-4表达水平存在一定的正相关性,ILT-4可能对HPV_(16/18)参与卵巢癌的发生、发展过程产生协同作用,值得关注。
Objective: To investigate the correlation between HPV16 / 18 infection and immunoglobulin like transposon-4 (ILT-4) expression in ovarian cancer patients. Methods: The patients with benign ovarian epithelial neoplasm (ovarian epithelial benign tumor), borderline neoplasm (borderline neoplasia) and ovarian cancer (ovarian neoplasia) who received definite diagnosis from January 2014 to December 2016 Forty-five subjects were selected as study subjects. Another 45 normal ovarian tissues were selected as control group. HPV16 / 18 and ILT-4 expression levels were detected by in situ hybridization, and HPV16 / 18 infection was analyzed and discussed Correlation with ILT-4 expression. Results: The positive rate of HPV16 (16/18) in ovarian cancer patients was higher than that in control group and benign ovarian epithelial tumor group (P <0.05). There was no significant difference between the two groups (P> 0.05). The level of ILT-4 in ovarian cancer patients was higher than that in normal control group, benign ovarian epithelial tumor group and borderline tumor group (P <0.05). CONCLUSION: In ovarian cancer, there is a positive correlation between HPV16 (16/18) infection and ILT-4 expression. ILT-4 may have a synergistic effect on HPV 16/18 involvement in the development of ovarian cancer, Worth attention.