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目的:观察β—内啡肽特异性拮抗剂纳络酮对肺性脑病昏迷的疗效。方法:将59例肺性脑病昏迷患者随机分为两组,在综合治疗基础上,治疗组加用纳络酮。对比分析两组清醒所需时间、清醒前后血气分析值和病死率。结果:治疗组清醒前后血气分析值无显著差异(P>0.05),治疗组与对照组相比,清醒所需时间短,病死率下降(P<0.05)。结论:纳络酮对肺性脑病昏迷具有催醒作用,其机理与综合治疗后清醒的机理不同。
Objective: To observe the curative effect of naloxone, a specific antagonist of β-endorphin, on coma of pulmonary encephalopathy. Methods: 59 patients with pulmonary encephalopathy were randomly divided into two groups. On the basis of comprehensive treatment, naloxone was added to the treatment group. Comparative analysis of two groups of time required for awake, before and after conscious blood gas analysis and mortality. Results: There was no significant difference (P> 0.05) in blood gas analysis before and after treatment in the treatment group. The time required for soberness was shorter and the case fatality rate was lower in the treatment group than in the control group (P <0.05). Conclusion: Naloxone has arousal effect on coma of pulmonary encephalopathy, and the mechanism is different from the mechanism of sober after the combination therapy.