抗-Cw同种异体免疫导致的胎儿水肿

• 作 者: Kollamparambil T.G. Jani B.R. Aldouri M. 朱新菊
• 机 构: Oliver Fisher Neonatal Unit Medway Maritime Hospital Windmill Road,Gillingham,Kent,ME7 5NY United K
• 出 处: 世界核心医学期刊文摘(儿科学分册)
• 发表日期: 2006年03期
• 关键词: 异体免疫 胎儿 水肿 溶血性疾病 红细胞抗原 脐带 血型系统 宫内输血 产前超声检查 抗体

Cw is a low frequency red cell antigen that belongs to the Rh blood groups system. While not uncommon, anti-Cw is rarely associated with clinically significant haemolytic disease of the newborn (HDN). When it does occur, it is often subclinical or of mild to moderate clinical severity. In the majority of pregnancies it is considered to be a naturally occurring antibody and has not been reported to cause hydrops fetalis or stillbirth. We report a case of anti-Cw alloimmunization, which was associated with significant anaemia and hydrops fetalis, presenting at 35 wk gestation. Conclusion: Pregnancies affected by anti-Cw merit closer scrutiny. Consideration should be given to performing more frequent antenatal ultrasound assessments to detect hydrops fetalis. This may help to support the need for more invasive procedures (cordocentesis and intrauterine transfusions).

Cw is a low frequency red cell antigen that belongs to the Rh blood groups system. While not uncommon, anti-Cw is rarely associated with clinically significant haemolytic disease of the newborn (HDN). When it does occur, it is often subclinical or of In the majority of pregnancies it is considered to be a natural occurring antibody and has not been reported to cause hydrops fetalis or stillbirth. We report a case of anti-Cw alloimmunization, which was associated with significant anemia and hydrops fetalis, presenting at 35 wk gestation. Conclusion: Pregnancies affected by anti-Cw merit closer scrutiny. Consideration should be given to performing more antenatal ultrasound assessments to detect hydrops fetalis. This may help to support the need for more invasive procedures (cordocentesis and intrauterine transfusions).