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目的:研究分析自身免疫性肝炎患者外周血淋巴细胞亚群的变化情况。方法:选取我院2014年12月-2015年2月我院收治的40例自身免疫性肝炎患者为研究组,另选同期50名健康体检者为对照组,经我院伦理委员会批准及受试者知情同意下采用FACSCA型流式细胞仪检测其外周血淋巴细胞亚群并进行比对分析。结果:研究组自身的外周血淋巴细胞亚群数值CD3+T、CD3+CD4+T、CD3+CD8+T、CD3+CD4+T/CD3+CD8+T、CD19+B、CD5+CD19+B、CD5+CD19+B/CD19+B、CD4+CD25+CD127dm T与对照组比较,差异具有统计学意义(P<0.05)。结论:自身免疫性肝炎患者外周血淋巴细胞亚群数值显著异于正常人,可以作为诊断肝损伤程度的参照指标。
Objective: To study the changes of peripheral blood lymphocyte subsets in patients with autoimmune hepatitis. Methods: Forty patients with autoimmune hepatitis treated in our hospital from December 2014 to February 2015 were selected as the research group and 50 healthy subjects were selected as the control group in the same period. The study was approved by the Ethics Committee of our hospital and tested Informed consent FACSCA-type flow cytometry was used to detect peripheral blood lymphocyte subsets and compared analysis. Results: The peripheral blood lymphocyte subsets in the study group were significantly lower than those in the control group (P <0.05) , CD5 + CD19 + B / CD19 + B, CD4 + CD25 + CD127dm T were significantly different from the control group (P <0.05). Conclusion: The values of peripheral blood lymphocyte subsets in patients with autoimmune hepatitis are significantly different from those in normal people, which may serve as a reference index for diagnosing the degree of liver injury.