【摘 要】
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Objective To study the effect of total body irradiation on the quantity and activity of P65,TNF α and IL 1 in irradiated rat wounds. Methods Tumor necrosis fac
【机 构】
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Institiute of Combined Injury, Third Military Medical University,Chongqing 400038,China
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Objective To study the effect of total body irradiation on the quantity and activity of P65,TNF α and IL 1 in irradiated rat wounds. Methods Tumor necrosis factor α (TNFα ) and interleukin 1 (IL 1 ) in wound fluids were quantified by ELISA and their biological activities were measured by L929 cell lysis and thymocyte proliferation,respectively. The expression of P65 protein in wounded tissue was determined by western blotting. Results The biological activities of TNF α and IL 1 in wound fluid decreased significantly after irradiation,while their quantities in wound fluids did not decrease significantly.The expression of P65 protein in wounded tissue also did not decrease obviously after irradiation. Conclusion These results suggestted that total body irradiation may inhibit the biological activities of TNF α , IL 1 and nuclear factor B,there may exist negative factors to disturb the protein functions in wound environments.
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