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目的:探讨 IL-18在溃疡性结肠炎(UC)发病中的作用。方法:采用固相酶联免疫分析(ELISA)法检测36例 UC 患者血清 IL-18含量。结果:UC 活动期患者血清 IL-18含量较健康对照组明显升高(P<0.01),并与病情的轻重和病变的范围有关(P<0.05),而 UC 缓解期患者与健康对照组间差异无显著性意义(P>0.05)。结论:IL-18可能参与 UC 的发病,血清 IL-18可作为 UC病情判断的参考指标。
Objective: To investigate the role of IL-18 in the pathogenesis of ulcerative colitis (UC). Methods: Serum IL-18 levels in 36 UC patients were detected by enzyme-linked immunosorbent assay (ELISA). Results: The serum level of IL-18 in active UC patients was significantly higher than that in healthy controls (P <0.01), and was related to the severity of the disease and the extent of the disease (P <0.05). However, There was no significant difference (P> 0.05). Conclusion: IL-18 may be involved in the pathogenesis of UC. Serum IL-18 may be used as a reference index for judging the severity of UC.