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目的:研究利多卡因在心肺复苏中对脑的保护作用。方法:随机选取2014年度到2015年度在我院进行急诊心肺复苏的患者56例,根据其急诊心肺复苏过程中是否使用利多卡因将其分为研究组和对照组,两组患者均使用肾上腺素、阿托品等常规药物进行复苏治疗,28例研究组患者在常规药物进行复苏的基础上加用利多卡因,同时选取10例健康志愿者,对比三组患者能够恢复自主循环(ROSC)后1h、1d、3d和7d的脑代谢指标差异。结果:ROSC后1小时和1d,研究和对照组患者SjvO_2、Ca-jvO_2和ERO_2对比差异不显著(P>0.05),但均与健康组存在显著差异(P<0.05);ROSC后3d,对照组SjvO_2显著高于研究组(P<0.05),研究显著高于健康组(P<0.05);ROSC后3d对照组Ca-jvO_2和ERO_2显著高于研究组(P<0.05),研究显著高于健康组(P<0.05);ROSC后7d,研究组和健康组SjvO_2、Ca-jvO_2和ERO_2对比差异不显著(P>0.05),均与对照组存在显著差异(P<0.05)。结论:利多卡因在心肺复苏患者中能够对患者进行脑保护,有利于患者恢复自主循环后的脑恢复。
Objective: To study the protective effect of lidocaine on brain during cardiopulmonary resuscitation. Methods: Fifty-six patients with emergency CPR were randomly selected in our hospital from 2014 to 2015, and were divided into study group and control group according to whether they used lidocaine during their emergency CPR. Both groups were given epinephrine , Atropine and other conventional drugs for recovery treatment. 28 patients in the study group were given lidocaine on the basis of conventional drug resuscitation while 10 healthy volunteers were selected. The patients in three groups were able to recover 1 h after spontaneous circulation (ROSC) 1d, 3d and 7d cerebral metabolic index differences. Results: At 1 hour and 1 day after ROSC, there was no significant difference in SjvO_2, Ca-jvO_2 and ERO_2 between study group and control group (P> 0.05), but there was significant difference between healthy group and control group (P <0.05) Group SjvO_2 was significantly higher than the study group (P <0.05), the study was significantly higher than the healthy group (P <0.05); Ca-jvO_2 and ERO_2 three days after ROSC control group was significantly higher than the study group (P <0.05) (P <0.05). There was no significant difference in SjvO_2, Ca-jvO_2 and ERO_2 between study group and healthy group on the 7th day after ROSC (P> 0.05), which were significantly different from the control group (P <0.05). CONCLUSION: Lidocaine protects brain in patients with cardiopulmonary resuscitation, which is beneficial to patients recovering from brain recovery after spontaneous circulation.