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Ｓｈｉｋａｍａ等对日本新宿大学医学院治疗的局部晚期乳腺癌患者的局部复发率进行了回顾性分析，以确定哪些病人在乳房切除术后需要给予胸壁照射。１９８４年～１９９４年期间 １０５例腋淋巴结转移数４个或有１个晚期原发肿瘤（Ｔ３～４Ｎａｎｙ）的乳腺癌病人在乳房切除术后
Shikama et al. Performed a retrospective analysis of the local recurrence rates in patients with locally advanced breast cancer treated with the Shinjuku University School of Medicine in Japan to determine which patients need chest wall irradiation after mastectomy. From 1984 to 1994, 105 breast cancer patients with axillary lymph node metastasis number 4 or 1 late stage primary tumor (T3 ~ 4Nany) after mastectomy