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目的检测并比较2型糖尿病(T2DM)及T2DM伴有糖尿病肾病(DN)患者血清超敏C-反应蛋白(CRP)及胱抑素C(Cysc)的水平变化,探讨联合检测对DN诊断的意义。方法依据24h尿蛋白的定量将90例T2DM患者分为3组,每组30例。A组:正常糖尿病肾病组(尿微量白蛋白定量UmALB<30mg/24h);B组:早期糖尿病肾病组(尿微量白蛋白定量UmALB≥30mg~300mg/24h);C组:临床糖尿病肾病(DN)组(尿微量白蛋白定量UmALB>300mg/24h);健康体检的(NC组)正常人对照组30例,分别计算各组的血清hs-CRP、CysC均值,并进行统计学分析。结果 A、B、C组血清hs-CRP及CysC水平均高于对照组,差异有统计学意义(P<0.05);B、C组血清hs-CRP及CysC水平均高于A组,差异有统计学意义(P<0.05),C组血清hs-CRP及CysC水平均高于B组,差异有统计学意义(P<0.05)。结论血清hs-CRP与CysC检测对2型糖尿病肾病早期诊断及病情监测具有重要的临床价值。
Objective To detect and compare the levels of serum high-sensitivity C-reactive protein (CRP) and cystatin C (Cysc) in type 2 diabetes mellitus (T2DM) and T2DM with diabetic nephropathy (DN), and to explore the significance of combined detection in the diagnosis of DN . Methods Ninety T2DM patients were divided into three groups according to the quantitation of 24h urinary protein, 30 cases in each group. Group A: normal diabetic nephropathy group (urinary microalbuminuria UmALB <30mg / 24h); group B: early diabetic nephropathy group (urine microalbuminuria UmALB≥30mg ~ 300mg / 24h); group C: clinical diabetic nephropathy ) Group (urine microalbuminuria UmALB> 300mg / 24h); healthy control group (NC group) normal control group of 30 patients were calculated serum hs-CRP, CysC mean, and statistical analysis. Results The serum levels of hs-CRP and CysC in groups A, B and C were significantly higher than those in control group (P <0.05). The serum levels of hs-CRP and CysC in groups B and C were higher than those in group A Statistical significance (P <0.05), serum hs-CRP and CysC levels in group C were higher than those in group B, the difference was statistically significant (P <0.05). Conclusion Serum hs-CRP and CysC detection of type 2 diabetic nephropathy early diagnosis and disease monitoring has important clinical value.