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目前公认,从皮肤或胃肠道吸收的维生素D首先要转送到肝脏,在肝脏转变成25-羟基维生素D,后者再转送到肾脏进行第二次羟基化,变成1,25-双羟基维生素D,然后才对靶细胞发生作用。现已证明,抗惊厥药由于促进维生素D及其生物活性产物的分解代谢的酶的作用,因而破坏上述的过程。在几组使用抗癫痫药治疗的癫痫病人中,10～30％病人有血清钙降低及硷性磷酸酶升高。虽然大部分病人生化异常是轻度的且临床表现较少,但也有因
It is currently recognized that vitamin D absorbed from the skin or gastrointestinal tract is first transferred to the liver and converted in the liver to 25-hydroxy vitamin D, which is then forwarded to the kidney for second hydroxylation to become 1,25-dihydroxy Vitamin D, and then the role of target cells. Anticonvulsants have been shown to disrupt the processes described above by enzymes that promote the catabolism of vitamin D and its biologically active products. Among several groups of patients with epilepsy treated with antiepileptic drugs, 10 to 30% of patients have decreased serum calcium and elevated alkaline phosphatase. Although most patients with biochemical abnormalities are mild and less clinical manifestations, but also because of