白细胞——内皮细胞粘附在缺血性中风发病机制中的作用

• 作 者: 陈云爽 陈槐卿
• 机 构: 华西医科大学生物医学工程研究室
• 出 处: 国外医学.生物医学工程分册
• 发表日期: 1999年02期
• 关键词: 缺血性中风 内皮细胞 白细胞计数 发病机制 粘附力 脑缺血 细胞因子 再灌注损伤 选择素家族 梗塞灶

缺血性中风为多发病和常见病。现在关于中风的发病机制已成为研究的热门课题，遗传、生化、生理、解剖、组织结构以及生物物理因素均在中风的发病过程中起了很重要的作用。最新研究报道，细胞因子和白细胞参与中风的起始及进展过程。在中风的高危因素如高血压、糖尿病等存在的条件下，白细胞激活及与内皮细胞的粘附，是中风发生、发展的关键因素。本文将对白细胞、内皮细胞及其与缺血性中风之间的关系作一综述。

Ischemic stroke is frequently-occurring disease and common disease. At present, the pathogenesis of stroke has become a hot topic in the study. Genetics, biochemistry, physiology, anatomy, tissue structure and biophysical factors play an important role in the pathogenesis of stroke. Recent studies report that cytokines and leukocytes participate in the initiation and progression of stroke. In the presence of stroke risk factors such as hypertension, diabetes and other conditions, leukocyte activation and endothelial cell adhesion, is the key to the occurrence and development of stroke. This article reviews the relationship between leukocytes, endothelial cells, and ischemic stroke.