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摘要：就运动中活性氧诱导肌原性IL-6产生的机制等问题做综述。IL-6是运动过程中变化非常明显的一种细胞因子，其变化幅度与运动时间和运动强度关系密切。研究表明，运动中生成的IL-6主要来源于收缩的骨骼肌，骨骼肌在运动过程中产生的自由基，尤其是活性氧是运动中诱导IL-6产生的一个主要原因。
关键词：运动生物化学；运动；活性氧；肌源性IL-6；综述
中图分类号：G804.7文献标识码：A文章编号：1006-7116(2009)05-0108-05
Review of signal transduction channels for active oxygen to induce the production of interleukin-6 originating from muscles during exercising
QIU Guo-rong1，2，XU Xiao-yang1，XIE Min-hao3
（1.School of Physical Education，South China Normal University，Guangzhou 510006，China；
2.Department of Physical Education，Chongqing University of Arts And Sciences，Yongchuan 402160，China；
3.Sport Science School，Beijing Sport University，Beijing 100086，China）
Abstract: The authors gave an overview of such issues as the mechanism for active oxygen to induce the production of interleukin-6 (IL-6) originating from muscles during exercising. IL-6 is a type of cytokine that changes very significantly in the process of exercising; its changing magnitude is closely related to exercise time and exercise intensity. Via their study the authors revealed the following findings: IL-6 produced during exercising originates primarily from contracting skeletal muscle; free radicals produced by skeletal muscle in the process of exercising, especially active oxygen, are a major cause for inducing the production of IL-6 during exercising.
Key words: sports biochemistry；exercising; active oxygen；muscle-originated IL-6；overview
从20世纪90年代中期发现运动中机体可以产生大量IL-6到现在，短短10余年时间，IL-6作为运动中变化最明显的细胞因子[1]，受到人们极大的关注。对于运动中产生的IL-6的功能已经有了较为广泛而深入的研究。如今，已不再简单地将IL-6定义为运动损伤的指标[2]，对于运动中IL-6的来源比较统一的认识是IL-6是由运动中的骨骼肌分泌而来[3-4]。已有的研究表明，肌原性IL-6在运动中机体能量代谢、内分泌和骨骼肌收缩等过程中扮演重要角色[5-6]。但对于引起IL-6在运动中大量分泌的因素却尚无定论。近期的研究表明，IL-6的产生与自由基代谢关系紧密，尤其与活性氧产生有关[7]。
活性氧的产生在需氧生物生命过程中是一个正常现象[8]。生理条件下，这些自由基大多数可以被细胞内的抗氧化系统清除。当机体处于运动等氧化应激状态时，活性氧生成速度大于抗氧化系统的清除速度，造成活性氧在体内的累积，对组织和细胞产生危害。不同刺激诱导细胞产生的内源性活性氧可以作为第二信使，通过改变氧化还原状态调节与细胞增殖、分化及凋亡相关
关键词：运动生物化学；运动；活性氧；肌源性IL-6；综述
中图分类号：G804.7文献标识码：A文章编号：1006-7116(2009)05-0108-05
Review of signal transduction channels for active oxygen to induce the production of interleukin-6 originating from muscles during exercising
QIU Guo-rong1，2，XU Xiao-yang1，XIE Min-hao3
（1.School of Physical Education，South China Normal University，Guangzhou 510006，China；
2.Department of Physical Education，Chongqing University of Arts And Sciences，Yongchuan 402160，China；
3.Sport Science School，Beijing Sport University，Beijing 100086，China）
Abstract: The authors gave an overview of such issues as the mechanism for active oxygen to induce the production of interleukin-6 (IL-6) originating from muscles during exercising. IL-6 is a type of cytokine that changes very significantly in the process of exercising; its changing magnitude is closely related to exercise time and exercise intensity. Via their study the authors revealed the following findings: IL-6 produced during exercising originates primarily from contracting skeletal muscle; free radicals produced by skeletal muscle in the process of exercising, especially active oxygen, are a major cause for inducing the production of IL-6 during exercising.
Key words: sports biochemistry；exercising; active oxygen；muscle-originated IL-6；overview
从20世纪90年代中期发现运动中机体可以产生大量IL-6到现在，短短10余年时间，IL-6作为运动中变化最明显的细胞因子[1]，受到人们极大的关注。对于运动中产生的IL-6的功能已经有了较为广泛而深入的研究。如今，已不再简单地将IL-6定义为运动损伤的指标[2]，对于运动中IL-6的来源比较统一的认识是IL-6是由运动中的骨骼肌分泌而来[3-4]。已有的研究表明，肌原性IL-6在运动中机体能量代谢、内分泌和骨骼肌收缩等过程中扮演重要角色[5-6]。但对于引起IL-6在运动中大量分泌的因素却尚无定论。近期的研究表明，IL-6的产生与自由基代谢关系紧密，尤其与活性氧产生有关[7]。
活性氧的产生在需氧生物生命过程中是一个正常现象[8]。生理条件下，这些自由基大多数可以被细胞内的抗氧化系统清除。当机体处于运动等氧化应激状态时，活性氧生成速度大于抗氧化系统的清除速度，造成活性氧在体内的累积，对组织和细胞产生危害。不同刺激诱导细胞产生的内源性活性氧可以作为第二信使，通过改变氧化还原状态调节与细胞增殖、分化及凋亡相关