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Objective The relationship between firing patt and sensitivity of neurons was studied in chronically compressed dorsal root ganglion (DRG) neurons and the Hindmarsh-Rose (HR) neuronal model. Methods Spontaneous activities from single fibers of chronically compressed DRG neurons in rats were recorded, and divided into periodic and non-periodic firing patts. The sensitivity of the two kinds of firing patt neuron to sympathetic stimulation (SS)was compared. Result It was found that 27.3% of periodic firing neurons and 93.2% of non-periodic firing neurons responded to SS respectively ( periodic vs non-periodic, P ＜ 0.01 ). The responses to SS with different stimulation time were greater non-periodic firing neurons than periodic firing neurons (P ＜ 0.01 ). The non-periodic firing neurons obviously responded to SS. After the firing patt of these neurons transformed to periodic firing patt, their responses to SS disappeared or decreased obviously. The HR neuronal model exhibited a significantly greater response to perturbation in non-periodic (chaotic) firing patt than in periodic firing patt. Conclusion The non-periodic firing neurons with deterministic chaos are more sensitive to extal stimuli than the periodic firing neurons.