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本文在小鼠不同来源造血干细胞性能研究的基础上,比较了其不同来源造血细胞的移植特性。依据对受体小鼠经致死量照射后的30天存活率观察,表明小鼠同系胎肝移植和骨髓移植的疗效相似;而异系间移植,则胎肝移植疗效优于骨髓移植;在异系间外周血细胞移植,则移植后死亡率明显高于照射对照组。文章同时对小鼠不同来源造血细胞移植疗效差异的机理进行了分析探讨,并认为对今后临床开展造血细胞移植提供了有价值的实验依据。
In this paper, based on the study of the different types of hematopoietic stem cells in mice, the characteristics of their transplantation from different sources were compared. Based on the 30-day survival rate of recipient mice after lethal dose irradiation, the results showed that the effect of mice with syngeneic fetal liver transplantation and bone marrow transplantation was similar; however, the effect of fetal liver transplantation was better than that of bone marrow transplantation; Department of peripheral blood cell transplantation, the mortality after transplantation was significantly higher than the irradiated control group. At the same time, the mechanism of different therapeutic effects on different types of hematopoietic stem cell transplantation in mice was analyzed and discussed, which provided valuable experimental evidence for future hematopoietic cell transplantation.