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目的观察低分子肝素钙联合氯吡格雷治疗不稳定型心绞痛(UAP)的临床效果及不良反应。方法将78例UAP患者随机分成治疗组(40例)和对照组(38例)。对照组采用常规治疗,观察组在常规治疗的基础上采用低分子肝素钙联合氯吡格雷治疗,观察两组患者的心绞痛症状改善情况、心电图变化、并发症的发生情况。结果心绞痛症状改善情况:治疗组总有效率为95.0%,对照组总有效率为71.1%,两组比较差异有统计学意义(χ2=6.802,P<0.05)。心电图变化:治疗组总有效率为90.0%,对照组总有效率为76.3%,两组比较差异有统计学意义(χ2=4.504,P<0.05)。两组患者均未出现严重出血并发症,主要是有轻微的注射部位渗血。结论低分子肝素钙联合氯吡格雷治疗UAP可显著提高疗效,且并发症少,有较好的安全性。
Objective To observe the clinical effects and adverse reactions of low molecular weight heparin combined with clopidogrel in the treatment of unstable angina pectoris (UAP). Methods 78 patients with UAP were randomly divided into treatment group (40 cases) and control group (38 cases). The control group was treated by conventional therapy. The observation group was treated with low molecular weight heparin and clopidogrel on the basis of routine treatment. The improvement of angina pectoris, electrocardiogram changes and complications were observed in both groups. Results The improvement of angina symptoms: The total effective rate was 95.0% in the treatment group and 71.1% in the control group. There was significant difference between the two groups (χ2 = 6.802, P <0.05). ECG changes: the total effective rate was 90.0% in the treatment group, the total effective rate was 76.3% in the control group, the difference between the two groups was statistically significant (χ2 = 4.504, P <0.05). No serious bleeding complications occurred in either group, with a slight bleeding at the injection site. Conclusion Low molecular weight heparin combined with clopidogrel can significantly improve the efficacy of UAP with fewer complications and better safety.