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本文观察奥美拉唑、羟氨苄青霉素、麦滋林-S对胃溃疡（GU）的疗效及其作用机理。218例患者随机分为三组，即对照组给奥美拉唑（20mg，qd，po）；二联组在对照组上加羟氨苄青霉素（500mg，tid，po，疗程6周）；三联组在二联组上加麦滋林-S（0．67g，tid，po），疗程均为6周。治疗前后测幽门螺杆菌（HP）、胃粘膜内前列腺素E2（PGE2）及生长抑素（SS），1年后观察GU的复发率。结果可见三联组疗效明显优于二联组（P＜0．05）及对照组（P＜0．01）。三联组、二联组HP的根除率明显高于对照组（P＜0.001），GU的复发率明显低于对照组（P＜0.001）。三联组用药后胃粘膜内PGE2、SS均明显升高（P＜0.05）。说明联合用药疗效优于单独用药，且HP的根除率高，GU的复发率低。
This article observed omeprazole, amoxicillin, Mai Zuolin-S on the efficacy of gastric ulcer (GU) and its mechanism of action. 218 patients were randomly divided into three groups, namely, the control group to omeprazole (20mg, qd, po); two groups in the control group, amoxicillin (500mg, tid, po, In the combined group on Gamazolin-S (0.67g, tid, po), treatment were 6 weeks. Helicobacter pylori (HP), prostaglandin E2 (PGE2) and somatostatin (SS) in gastric mucosa were measured before and after treatment. The relapse rate of GU was observed one year later. The results showed that triple effect group was significantly better than the two groups (P <0.05) and the control group (P <0.01). The eradication rates of HP in triple group and dual group were significantly higher than those in control group (P <0.001). The recurrence rate of GU was significantly lower than that in control group (P <0.001). The gastric mucosal PGE2 and SS in the triple group were significantly increased (P <0.05). Description of combination therapy is superior to the single drug, and HP eradication rate is high, GU recurrence rate is low.