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目的探究梅毒血清抵抗患者临床分析及免疫功能研究。方法选取于2012年6月-2014年3月在本院进行治疗的60例梅毒血清抵抗患者,将其作为观察组,同时选取60例健康人员作为对照组,分析观察组患者梅毒血清抵抗的发生和甲苯胺红不加热血清实验(TRUST)的初始滴度、治疗用药、疾病分期的关系,最后比较2组患者的外周血淋巴细胞亚群比例。结果观察组患者中,56例患者使用苄星青霉素规范驱梅治疗,3例患者因为青霉素过敏最后选择使用头孢进行治疗,剩下的1例患者使用罗世芬进行治疗。和对照组相比较,观察组患者的CD4+和NK细胞比例分别从38.03±8.04、22.35±7.85下降到32.14±6.37、17.96±7.67,观察组患者的CD4+和NK细胞比例明显低于对照组,2组结果对比差异有统计学意义(P<0.05)。结论 CD4+和NK细胞比例下降,初始滴度低,可能和梅毒血清抵抗有关系。
Objective To investigate the clinical analysis and immune function of syphilis serum resistance patients. Methods A total of 60 syphilis serum resistant patients treated in our hospital from June 2012 to March 2014 were selected as the observation group and 60 healthy individuals were selected as the control group to analyze the occurrence of syphilis serum resistance in the observation group And the initial titer of TRUST, therapeutic drug and disease stage, and finally the proportion of peripheral blood lymphocyte subsets between the two groups was compared. Results In the observation group, 56 patients were treated with benzathine penicillin, and 3 patients were treated with cephalosporin because of penicillin allergy. The remaining 1 patient was treated with ropivacaine. Compared with the control group, the proportion of CD4 + and NK cells in observation group decreased from 38.03 ± 8.04,22.35 ± 7.85 to 32.14 ± 6.37,17.96 ± 7.67 respectively, and the proportion of CD4 + and NK cells in observation group was significantly lower than that in control group. 2 There was significant difference between the two groups (P <0.05). Conclusion The proportion of CD4 + and NK cells is decreased, and the initial titer is low, which may be related to syphilis serum resistance.