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目的观察放疗联合多西他赛、顺铂治疗鳞状细胞癌的疗效及不良反应。方法对65例鳞状细胞癌患者根据不同的治疗方法分为两组:单放组和放化组。单放组32例,采用常规视野放疗;放化组33例,采用多西他赛每周同步方案。两组均随5年。结果放化组有效率分别为18.2%和69.7%,而放疗组分别是6.3%和46.9%。两组有效率差异有统计学意义(P<0.05)。放化组和放疗组2年、5年生存率差异有统计学意义(P<0.05)。结论同步放化疗优于单纯放疗,不良反应能耐受,可明显提鳞状细胞癌的疗效。
Objective To observe the efficacy and adverse reactions of radiotherapy combined with docetaxel and cisplatin in the treatment of squamous cell carcinoma. Methods 65 cases of squamous cell carcinoma patients according to different treatment methods are divided into two groups: single release group and radiotherapy group. In group A, 32 cases were treated with routine field radiotherapy, while 33 cases in radiotherapy group were given weekly weekly docetaxel regimen. Both groups followed 5 years. The results of the radiotherapy and chemotherapy group were 18.2% and 69.7%, respectively, while the radiotherapy group were 6.3% and 46.9%. The difference between the two groups was statistically significant (P <0.05). The 2-year and 5-year survival rates of radiotherapy group and radiotherapy group were significantly different (P <0.05). Conclusions Simultaneous chemoradiotherapy is superior to radiotherapy alone, and adverse reactions can be tolerated, which can obviously improve the curative effect of squamous cell carcinoma.