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目的探讨不同剂量辛伐他汀治疗脑梗死的临床疗效。方法选取2013年1月—2014年5月广西医科大学第十附属医院收治的脑梗死患者126例,根据住院尾号的奇偶分为试验组64例与对照组62例。对照组患者予以20mg辛伐他汀治疗,试验组患者予以40mg辛伐他汀治疗。观察两组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、神经功能恢复正常时间、治疗时间、临床疗效及不良反应发生情况。结果治疗前两组患者NIHSS评分比较,差异无统计学意义(P>0.05);治疗后试验组患者NIHSS评分低于对照组,差异有统计学意义(P<0.05);试验组患者神经功能恢复正常时间、治疗时间短于对照组,总有效率高于对照组,不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论 40mg辛伐他汀治疗脑梗死的临床疗效显著,可改善患者神经功能,且不良反应少,安全性高。
Objective To investigate the clinical effects of different doses of simvastatin on cerebral infarction. Methods 126 patients with cerebral infarction admitted to the Tenth Affiliated Hospital of Guangxi Medical University from January 2013 to May 2014 were divided into 64 cases in the experimental group and 62 cases in the control group according to the parity of hospitalization tail number. Patients in the control group received 20 mg of simvastatin and patients in the test group received 40 mg of simvastatin. The National Institutes of Health Stroke Scale (NIHSS) score, normal nerve function recovery time, treatment time, clinical efficacy and adverse reactions were observed before and after treatment in both groups. Results There was no significant difference in NIHSS score between the two groups before treatment (P> 0.05). NIHSS score of the experimental group was lower than that of the control group after treatment (P <0.05) The normal time, treatment time was shorter than the control group, the total effective rate was higher than the control group, the incidence of adverse reactions was lower than the control group, the difference was statistically significant (P <0.05). Conclusion 40mg simvastatin treatment of cerebral infarction significant clinical effect, can improve the patient’s neurological function, and less adverse reactions, high safety.