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为了探讨慢性病毒性肝炎的发病机理，应用ELISA方法分别对75例慢性过延性肝炎、慢性活动性肝炎、慢性重症肝炎、肝炎后肝硬化患者血清白细胞介素4（IL—4）、白细胞介素6（IL－6）含量进行了检测，同时探讨了IL—6含量变化与血清胆红素水平及凝血酶原活动度的关系，结果表明，各级病人血清IL－4含量与对照组比较无明显差别（P＞0．05）；各组病人中IL－6含量与对照组比较明显升高（P＜0．01），以慢性重症肝炎为最高，说明IL－6在慢性肝炎的发生发展中起一定作用；该组病人共75例，其中IL－6水平与血清胆红素水平呈明显正相关，与凝血酶原活动度（FTA）呈明显负相关，提示IL－6可以反映肝细胞坏死程度，可以做为判断肝脏功能的又一实验室指标。
In order to explore the pathogenesis of chronic viral hepatitis, 75 cases of chronic hepatitis, chronic active hepatitis, chronic severe hepatitis, post-hepatitis cirrhosis patients with serum interleukin 4 (IL-4), interleukin 6 (IL-6) were detected. The relationship between IL-6 content and serum bilirubin level and prothrombin activity was also explored. The results showed that there was no significant difference in serum IL-4 level between the two groups (P> 0.05). The content of IL-6 in each group was significantly higher than that in the control group (P <0.01), and was highest in chronic severe hepatitis, indicating that IL-6 was involved in the development of chronic hepatitis Play a role in this group of patients a total of 75 cases, including IL-6 levels and serum bilirubin levels was positively correlated with prothrombin activity (FTA) showed a significant negative correlation, suggesting that IL-6 can reflect liver cell necrosis The extent of liver function can be used as another laboratory indicators.