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目的:观察以雷贝拉唑、左氧氟沙星为基础的三联疗法对幽门螺杆菌根除失败的补救疗法的临床疗效。方法:幽门螺杆菌根除失败的患者50例,予雷贝拉唑20mg,阿莫西林1.0,一天两次;左氧氟沙星0.5,一天一次;口服一周。停药1个月后行13 C呼气试验检测来判断幽门螺杆菌根除率。结果:49例完成了整个研究过程,意向处理分析(ITT)根除率为82.00%,完成治疗分析(PP)根除率为83.67%,总的副作用发生率为12.00%,症状缓解率95.92%。结论:以雷贝拉唑、左氧氟沙星为基础的短程三联疗法对根治失败的幽门螺旋杆菌感染患者是一种安全、有效的治疗方案。
OBJECTIVE: To observe the clinical efficacy of triple therapy with rabeprazole and levofloxacin in the treatment of Helicobacter pylori eradication failure. Methods: 50 cases of failure of helicobacter pylori eradication, pre-rabeprazole 20mg, amoxicillin 1.0, twice a day; levofloxacin 0.5, once a day; orally for one week. One month after discontinuation of 13 C breath test to determine the Helicobacter pylori eradication rate. Results: The study was completed in 49 cases. The ITT eradication rate was 82.00%. The complete treatment analysis (PP) eradication rate was 83.67%. The overall incidence of side effects was 12.00%. The rate of symptom relief was 95.92%. Conclusions: Short-range triple therapy based on rabeprazole and levofloxacin is a safe and effective treatment for patients with H. pylori infection who have failed radical treatment.