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目的 为探讨超广谱β-内酰胺酶(ESBLs)细菌感染耐药情况及防治措施。方法 将2000年4月-2003年4月三年间在我院新生儿病房收治的危重新生儿经细菌培养共59例分成两组,2000年4月-2001年10月为第一组共31例;2001年11月-2003年4月为第二组共28例。结果 第一组细菌培养阳性12例,ESBLs阳性6例;第二组阳性10例,ESBLs阳性仅1例,对未采取防治措施前后两组进行统计分析,P<0.01,差异有显著性。结论 表明加强新生儿病房的消毒隔离制度,对ESBLs感染患儿进行隔离,立即停用三代头孢菌素,根据药敏调整抗生素,对ESBLs感染采取有效防治措施后要可减少耐药菌的发生。
Objective To investigate the drug resistance of extended-spectrum β-lactamase (ESBLs) bacterial infections and its prevention and treatment. Methods From April 2000 to April 2003 three years in our hospital neonatal ward admitted critically ill newborns by bacterial culture a total of 59 cases were divided into two groups, April 2000 - October 2001 for the first group of 31 cases ; November 2001 - April 2003 for the second group of 28 cases. Results The first group of bacteria culture positive in 12 cases, ESBLs positive in 6 cases; the second group of positive in 10 cases, ESBLs positive in only 1 case, without taking preventive and control measures before and after the two groups were statistically analyzed, P <0.01, the difference was significant. The conclusion shows that it is necessary to strengthen the disinfection and isolation system of newborn ward, isolate the children with ESBLs infection, stop the third generation cephalosporins immediately, adjust the antibiotics according to the drug susceptibility, and take effective control measures against ESBLs infection to reduce the occurrence of drug-resistant bacteria.