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目的研究肺癌体外化疗药物敏感性与临床疗效的关系,为临床化疗方案的个体化选择提供依据。方法60例非小细胞肺癌病例入组,试验组使用ATP-TCA方法测定肺癌组织中肿瘤细胞的化疗药物敏感性,并依据敏感结果选择化疗方案;对照组选择NP方案。观察临床近期疗效和远期生存率。结果试验组有效率43.48%,2年生存率34.78%,高于NP方案组的37.04%和25.92%,但是两组之间没有明显差异。结论依靠体外药敏试验结果指导化疗方案的制定可能有助于肺癌化疗疗效的提高。
Objective To study the relationship between the chemosensitivity of chemotherapeutic drugs and the clinical efficacy in vitro and to provide evidence for the individualized selection of clinical chemotherapy regimens. Methods Sixty cases of non-small cell lung cancer were enrolled in the study. The experimental group was used to measure the chemosensitivity of tumor cells in lung cancer tissue by ATP-TCA method. The chemotherapy regimen was chosen according to the sensitive result. The NP regimen was chosen as the control group. To observe the clinical short-term efficacy and long-term survival. Results The effective rate was 43.48% in the trial group and 34.78% in the 2-year survival group, which was higher than 37.04% and 25.92% of the NP group, but there was no significant difference between the two groups. Conclusion The development of drug regimen relying on drug susceptibility test results in vitro may contribute to the improvement of the efficacy of chemotherapy for lung cancer.