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复方马钱子汤免疫药理学研究表明该复方能抑制小鼠巨噬细胞吞噬功能(P<0.001),抑制小鼠血清溶血素生成和血清IgG水平(P<0.001,P<0.01),抑制小鼠ANAE(P<0.001),抑制由DNCB引发的小鼠耳壳DTH(P<0.001),和由SRBC引发的小鼠足垫DTH(P<0.01)。对小鼠胸腺呈抑制作用(P<0.01～0.001),对脾脏影响不明显(P>0.05)。Cy造成小鼠免疫低下状态,复方对由SRBC引发的小鼠DTH呈促进现象(P<0.05～0.01),及提高小鼠血清IgG水平(P<0.01),表现免疫调节作用,剂量对效应有较大影响。
The immunological pharmacology study of Compound Maqinzi Decoction showed that the compound can inhibit the phagocytosis of macrophages in mice (P<0.001), inhibit the serum hemolysin production and serum IgG levels in mice (P<0.001, P<0.01). Rat ANAE (P<0.001) inhibited DNCB-induced ear shell DTH in mice (P<0.001), and SRBC-induced mouse footpad DTH (P<0.01). The thymus of mice was inhibited (P<0.01-0.001), and the effect on the spleen was not obvious (P>0.05). Cy contributes to the immunocompromised state of mice, compound promotes DTH induced by SRBC (P<0.05-0.01), raises serum IgG level in mice (P<0.01), shows immunoregulatory effects, and has dose-response effects. Big impact.