侵性乙肝肝硬化发展自然病程的前瞻性研究

• 作 者: 朱国静
• 出 处: 国外医学(内科学分册)
• 发表日期: 1990年08期
• 关键词: 乙肝肝硬化 抗病毒 慢性肝炎 DNA 免疫抑制治疗 清抗 肝活检 病毒血清学 肝脏组织学 静脉曲张破裂

本文对960例 HBsAg 阳性慢性肝炎随访10年,其中76例(男72、女4)发展为肝硬化,年龄23～71(41.3±10.6)岁。患者分两组:第一组43例(56.6%),血清 HBeAg 和/或 HBV-DNA 阳性;第二组33例(43.3%),血清 HBeAg 和 HBV-DNA 阴性,11例血清抗-HD 阳性。76例均无饮酒、药瘾、输血、同性恋、接受抗病毒或免疫抑制治疗史。

In this paper, 960 cases of HBsAg positive chronic hepatitis were followed up for 10 years, of which 76 (male 72, female 4) developed cirrhosis, aged from 23 to 71 (41.3 ± 10.6) years. The patients were divided into two groups: 43 cases (56.6%) in the first group had positive serum HBeAg and / or HBV-DNA; 33 cases (43.3%) in the second group had negative serum HBeAg and HBV-DNA and 11 positive serum anti-HD . None of the 76 patients had alcohol, drug addiction, blood transfusion, homosexuality, history of antiviral or immunosuppressive therapy.