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应用一次法口服4mg／kg的米非司酮（RU486），观察17例单纯性肥胖和7例疑似库欣组的病人服药前后的反应，并与10例正常人以及29例库欣综合征病人进行比较，发现库欣综合征病人服药以后，血F、24小时尿F及血ACTH均无显著性变化（（P＞005），而其他三组各指标均升高（P＜0．01）。并得出鉴别库欣综合征与非库欣综合征的标准为：血F增加的百分比为30％，24小时尿F增加百分比为18％，ACTH增加百分比为17％。该试验诊断敏感性为89．6％，特异性为94．1％，准确性为92．l％。
A single oral administration of 4 mg / kg of mifepristone (RU486) was used to observe the response of 17 patients with simple obesity and 7 patients with suspected Cushing injection before and after taking the drug. The results were compared with 10 healthy controls and 29 Cushing’s syndrome patients (P> 0.05). However, no significant changes were found in blood F, 24-hour urinary F and blood ACTH after Cushing’s syndrome patients were treated (P> 0.05), while the other three groups were all increased (P <0.01) The criteria for distinguishing between Cushing’s syndrome and non-Cushing’s syndrome are: 30% increase in blood F, 18% increase in urinary F at 24 hours, and 17% increase in ACTH. This test diagnoses sensitivity 89.6%, specificity 94.1%, accuracy 92.l%.