Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide

• 作 者: Xia Zhu Kang Chao Miao Li Wen
• 机 构: InstituteofClinicalPharmacology,DepartmentofGastroenterology,CenterforPharmacogeneticsandDepartmento
• 出 处: 世界胃肠病学杂志:英文版
• 发表日期: 2019年38期
• 关键词: Crohn’s disease Thioguanine NUCLEOTIDE levels NUCLEOSIDE diphosphatelinked MOIET
• 基金项目: the National Natural Science Foundation of China,No.81573507,No.81473283,No.81173131,and No.81320108027,Guangdong Provincial Key Laboratory Construction Foundation,No.2017B030314030,The National Key R

BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensiti