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目的 探讨后ACSOG Z0011时代术中冰冻病理诊断在乳腺癌前哨淋巴结活检中的价值.方法 连续收集就诊于北京大学人民医院乳腺中心的浸润性乳腺癌患者,术中前哨淋巴结行冰冻病理检查,按术后石蜡病理结果统计分析冰冻病理的准确性;按Z0011入组标准分析前哨淋巴结冰冻病理诊断对后续腋窝处理的影响.结果 395例入组患者中前哨淋巴结术中冰冻病理阳性59例,阴性336例,冰冻切片的假阴性率为21.3％,敏感度为78.7％.在59例阳性患者中,按Z0011入组标准统计分析,26人(44.1％)可避免腋窝淋巴结清扫术;而在接受保乳手术患者中,该比例为92.9％.结论 对于T1-2期、术前腋窝淋巴结临床阴性、拟行保乳手术的乳腺癌患者,可不行术中冰冻切片检查.“,”Objective To explore the value of intraoperative frozen section at sentinel lymph nodesbiopsy(SLNB) of breast cancer in post ACSOG Z0011 era.Methods Invasive breast cancer patients underwent SLNB at Peking University People's Hospital were collected continuously.Sentinel lymph nodes of all patients were received frozen section.The accuracy were analyzed according postoperative paraffin section.The influence of frozen section on axillary lymph node dissection (ALND) were analyzed according including criterion of Z0011 study.Results In all 395 cases,59 positive cases and 336 negative cases were detected in frozen sections.The false-negative rate and sensitivity of frozen section were 21.3％ and 78.7％ respectively.For 59 positive SLN patients,26 (44.1％) patients could avoid ALND according including criterion of Z0011 study,and it was 65.5％ in patients who received lumpectomy.Conclusions For patiems who will receive lumpectomy,with tumor size T1-2 and clinical negative axillary lymph nodes preoperatively,the intraoperative frozen section for SLN could be avoided.