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自1785年洋地黄用于临床以来,至今已有二百多年,到目前为止,仍是治疗心力衰竭最有效的药物之一。近年来,虽然对洋地黄的作用机制,药代动力学、药效动力学以及临床投药方法的研究有了重大进展,但洋地黄中毒的发生率仍然较高,本文我院1980～1995年期间收治的老年人洋地黄中毒病例进行分析,以探讨老年人洋地黄中毒的临床特点。 1 材料与方法 27例病人中,男17例,女10例,平均年龄64.5岁(60～74岁)。基础心脏病:冠心病10例,高心病5例,肺心病5例,风心病4例,扩张型心肌病3例。心功能(按NYHA分级)Ⅱ级2例,Ⅲ级10例,Ⅳ级15例,其中反复心衰16例。单用地戈辛维持量治疗22例,地高辛+西地兰治疗3例,顿服地戈辛7.5mgl例,不规则用药1例。
Since 1785, digitalis has been used clinically for more than 200 years and so far it is still one of the most effective drugs for the treatment of heart failure. In recent years, although the mechanism of action of digitalis, pharmacokinetics, pharmacodynamics and clinical methods of administration have made significant progress, but the incidence of digitalis poisoning is still high, this hospital in our hospital from 1980 to 1995 Admitted to the elderly digitalis poisoning cases were analyzed to explore the clinical features of digitalis poisoning in the elderly. 1 Materials and Methods 27 patients, 17 males and 10 females, average age 64.5 years (60-74 years old). Basic heart disease: coronary heart disease in 10 cases, 5 cases of high heart disease, pulmonary heart disease in 5 cases, 4 cases of rheumatic heart disease, dilated cardiomyopathy in 3 cases. Heart function (NYHA classification) Ⅱ grade in 2 cases, Ⅲ grade in 10 cases, Ⅳ grade in 15 cases, of which 16 cases of repeated heart failure. In the study, 22 cases were treated with Geoxim alone, 3 cases with digoxin + cedilanid, 7 cases with Geoxing 7.5 mg daily and 1 case with irregular medication.